2022 American Transplant Congress
Alloimmunization Against Red Blood Cell Antigens is Not Associated with Increased All Cause Mortality in Liver Transplant Recipients
*Purpose: Liver transplantation (LT) is a life‐saving procedure for patients with end‐stage liver disease and transfusion therapy of LT patients remains a challenge. Improvement of…2022 American Transplant Congress
Protein and Transcriptomic Differences Between High and Low Neointimal Arteries in Human Cardiac Allograft Vasculopathy Rejected Grafts
*Purpose: Cardiac allograft vasculopathy (CAV) is the leading cause of graft failure and mortality following heart transplantation. Donor specific antibodies (DSA) contribute to CAV progression…2022 American Transplant Congress
Prolonged Xeno-Kidney Graft Survival in Highly Allo-Sensitized Nonhuman Primate Using Triple-Knockout Donor Pigs with 7 Human Transgenes
*Purpose: We have previously shown using porcine kidneys from genetically modified knockout alpha 1,3-galactosyltransferase (GGTA1KO) and human decay accelerating factor transgenic (CD55Tg) pigs that compared…2022 American Transplant Congress
Fcγ Receptor-Positive Cells Play a Critical Role in Rejection of Allogeneic Bone Marrow Cells Mediated by Anti-Donor Antibodies
1Talaris, Louisville, KY, 2Talaris Therapeutics, Louisville, KY
*Purpose: Sensitization through prior exposure to MHC antigens results in an increased rate of graft rejection. We previously reported that humoral immunity is the primary…2022 American Transplant Congress
Non-HLA Antibodies to G Protein-Coupled Receptors and Allograft Survival in Pediatric Kidney Transplant Recipients: Short- and Long-Term Outcomes
*Purpose: We have recently shown that the non-HLA antibodies to angiotensin II type 1 receptor (AT1R-Ab) and endothelin-1 type A receptor (ETAR-Ab) are prevalent and…2022 American Transplant Congress
Regulatory T Cells Suppress Memory IL-17a Production in Highly Sensitised Patients with End-Stage Renal Disease
*Purpose: Highly sensitised patients exhibit poorer long-term outcomes following renal transplantation compared to those non sensitised individuals. IL17-A has been associated with acute rejection. Presence…2022 American Transplant Congress
Belatacept-Based Maintenance Immunosuppression Promoted Long-Term Antibody-Mediated Rejection Free Graft Survival After Desensitization in Sensitized Multiparous Female Recipients
Duke Transplant Center, Durham, NC
*Purpose: Amongst sensitized patients awaiting a transplant, females are disproportionately represented. To date, nonhuman primate (NHP) models of transplantation have relied on male animals, sensitized…2022 American Transplant Congress
Effect of CD8+ Cell Depletion in Treg Mediated Skin Graft Survival
*Purpose: The selective in vivo expansion and activation of regulatory T cells via administration of interleukin-2 (IL-2) coupled to a specific antibody against IL-2 (IL-2…2022 American Transplant Congress
Outcomes of Hlai Kidney Transplants in Patients with Cpra 100% After Desensitization
*Purpose: The KAS implementation was aimed at increasing access to kidney transplantation in highly HLA sensitized (HS) patients. However, combining desensitization (DES) + KAS could…2022 American Transplant Congress
Impact of Belatacept on Clinical Outcomes in Lung Transplant Patients with Antibody-Mediated Rejection
*Purpose: Antibody-mediated rejection (AMR) is cause of significant morbidity and mortality in lung transplant recipients (LTRs). An optimal therapeutic regimen is still lacking. Recent evidence…
- 1
- 2
- 3
- …
- 40
- Next Page »