2022 American Transplant Congress
Domino Living Donor Kidney Transplant Following Therapeutic Nephrectomy for Renal Artery Stenosis with Arterial Reconstruction and Viability Assessment Using Ex Vivo Normothermic Perfusion: A Case Series
*Purpose: Ex vivo normothermic perfusion (EVNP) is increasingly recognized as a viability tool to increase organ utilization. We report use of EVNP to assess graft…2022 American Transplant Congress
Use of Pronase to Identify HLA Crossmatch Antibody Interference
*Purpose: Solid organ transplant centers should maintain vigilance that antibody therapies can impact HLA crossmatch results.*Methods: N/A*Results: A 46-year-old man with Mayo stage IV cardiac…2022 American Transplant Congress
Multiomic Analyses Of Two Pig Kidney To Human Xenotransplants
*Purpose: Organ shortage remains a major limitation within transplantation, with waiting lists greatly outpacing the number of donors available. Pig organs offer significant advantages for…2022 American Transplant Congress
Fibroblastic Reticular Cell Lama4 Regulates T Cell Migration to Lymph Nodes and Adaptive Immunity
1Surgery, UMB, Baltimore, MD, 2Harvard University, Boston, MA
*Purpose: Lymph node (LN) stromal laminin α4 (Lama4) is associated with tolerance. We hypothesized that fibroblastic reticular cell (FRC) derived Lama4 contributes to a tolerogenic…2022 American Transplant Congress
Bystander Suppression: Enhancing the Power of Ex Vivo Expanded Antigen Specific Regulatory Cell Lines
*Purpose: The potential of T regulatory cell (Treg) based therapies in transplantation has been demonstrated in various preclinical models. Multiple clinical trials are currently undergoing…2022 American Transplant Congress
Exosomal TGFbeta:LAP as Immunosuppressive Mediator of Allo-Tolerance
*Purpose: TGFβ has long been known as a key component in tolerance mediated by Treg cells. Here we show that, unlike IL10, but like CD39/CD73,…2022 American Transplant Congress
Impact of the Weekend Effect on Adult and Pediatric Liver or Kidney Offer Acceptance
Transplant Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA
*Purpose: Weekends may impose resource and manpower constraints on hospitals. Studies using data from prior allocation schemas showed increased adult organ discards on weekends. We…2022 American Transplant Congress
Resistance Isn’t Futile: The Independent Effect of Pumping Resistance on Long-Term Kidney Graft Survival
*Purpose: Kidneys are pumped for therapeutic (to mitigate deleterious effects of ischemia), practical (to facilitate transplant scheduling), and prognostic (to assess organ quality) purposes. Yet…2022 American Transplant Congress
The Ontario Anatomic Kidney Score (OAKS) : Quantitative Macroscopic Assessment versus Histological Grading in Pre-transplant Evaluation of Donor Kidneys
*Purpose: Quantitative gross assessment of a kidney has not been used to influence the evaluation to utilize a kidney for transplantation. The Ontario Anatomic Kidney…2022 American Transplant Congress
Utilizing Microporous Annealed Particle (MAP) Gel as an Immunomodulatory Carrier for Islet Delivery
*Purpose: To investigate if coating with MAP gel improves dissociated or whole islet transplantation outcome.*Background: MAP gel platform technology is composed of hydrogel microspheres that…
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